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doi: 10.1038/ncomms12276 108 BurnhamELHalkarRBurksMMossM

The upregulation of Bax and suppression of Bcl-2 in the DEX group indicate a shift toward pro-apoptotic signalling

This can lead to pancreatitis and other metabolic issues if left unresolved

For older adults on long-term PPIs, periodic B12 monitoring is appropriate and a daily sublingual methylcobalamin is a reasonable preventive measure to discuss with the prescriber