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Description

Neurotoxicity There is a great deal of evidence that flavonoidsprimarily, hesperidin, hesperetin and quercetinhave protective effects on the nervous system, when it is subjected to exogenous neurotoxic type aggressions, or as a consequence of endogenous toxicity dependent on metabolic disorders (diabetes) or mediators of the inflammation

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Moreover, black cumin and TQ were shown to protect against various chemical-induced neuronal injury in experimental conditions (Table 1)

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While higher doses (particularly 54 mg) showed some increase in gastrointestinal-related events, these remained mild to moderate in severity and did not result in treatment discontinuation

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4, severe injury (Widespread loss of the brush border and tubular dilation in tubules, with cast formation commonly observed.)

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