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doi: 10.1038/s41590-021-00993-3 103 JiaJWangMMengJMaYWangYMiaoNet al

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How the Liver Handles Tylenol The liver metabolizes almost all of it (see diagram above): 90% : Processed safely through glucuronidation and sulfation 2%: Eliminated through the kidneys (urine) 510% : Processed by the enzyme CYP2E1 creates a toxic byproduct called NAPQI (N-acetyl-p-benzoquinone imine)

(2022b, December 8)

The review described the interplay of these systems as constituting a coordinated, multi-layered defence network centred on GSH availability

Your clinician will manage titrationslowly adjusting your medication to find the right doseand provide practical strategies to prevent or manage side effects