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Faria et al

All 11 cases of JHR in the ceftriaxone group presented with fever (100%, 11/11)

J.HeitmanJ.WellingtonM.ChenY

148 In this context, calcium mobilization and subsequent activation of CaMKK activate AMPK, which might modulate mTORC2 signaling, possibly through direct phosphorylation of mTOR

If certain microbial changes consistently precede disease onset by years (as constipation does in PD), it strengthens the case for causality and prevention