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However, additional competitive and syntrophic interactions may exist between microbes for cobalamin in the GI tract and to what extent this impacts bacterial pathogenesis in the gut remains poorly understood

PLoS ONE 9 , e106342 (2014)

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By comparing the gene expression profiles of the skin microbiota in acne patients with the profiles from healthy individuals, the vitamin B 12 biosynthesis pathway in the skin bacterium Propionibacterium acnes turned out to be significantly down-regulated in acne patients

We have improved his formula by adding Biotin, B6, and Chromium