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74,77 A study in fibromyalgia patients showed their muscle oxygen use was lower, a possible sign of reduced mitochondrial energy production, and did not increase during exercise

The combination of improved sleep and reduced pain perception could create a virtuous cycle for those dealing with chronic pain conditions, where poor sleep and pain often reinforce each other

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Discussion Here, we identified three major inflammatory areas in our inflammation model based on the macrophage polarization and their cellular neighborhoods, whereby an inflammatory core region including the pathogen is surrounded by a proinflammatory region containing M1like macrophages and an outer region containing antiinflammatory cells

doi: 10.1007/s00383-020-04762-5 164 MokhtariT.AkbariM.MalekF.KashaniI