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Cholesterol-induced mitochondrial dysfunction is strongly correlated with hepatic OxE, suggesting that therapeutic strategies to restore mitochondrial homeostasis may be key to MASLD treatment

Thus, studies have suggested that peroxisome proliferator-activated receptor gamma (PPAR-) may play a key role in modulating the inflammatory and fibrotic responses in the lung 19,75

Since GGT plays a significant role in cancer cells to produce GSH to relieve oxidative stress, inhibiting the GGT activity would lead to elevated ROS levels 39

T14 plays a trophic role in early development through the calcium signaling of 7-nAChR, but the tolerance of neurons to calcium ion flux significantly decreases in the elderly (Graur et al., 2023)