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As a result, the distribution of occludin within the intercellular junction complex decreases, the interstitial space expands, and endotoxins, including bacterial LPS, can enter the portal circulation (Li et al., 2013)

10.1016/S0896-6273(01)00264-1 Neuron 148 PratM.CrepaldiT.PennacchiettiS.BussolinoF.ComoglioP

In a phase 3 trial involving adults with overweight or obesity (BMI 28 kg/m, or 24 kg/m with at least one weight-related comorbidity) without diabetes, treatment with 2.4 mg ecnoglutide produced a mean body weight reduction of 13.2% at 40 weeks