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Treatment with the channel blockers alone or in combination with negative control 11 resulted in insignificant decrease of the GSH/GSSG ratio and no effect on adult worm viability

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Metabolic activity assays in intact RBCs Washed RBCs were prepared in isotonic HEPES buffer containing either (i) 5 mM [U 13 C]-glucose (Isotec), (ii) 5 mM glucose, 5 mM alanine, and 5 mM [ 13 C 1,2,3,4 ]--ketoglutarate (Cambridge Isotope Laboratories) or (iii) 5 mM glucose and 1 mM [U 13 C 15 N] glutamine

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As a key transcription factor, NRF2 regulates antioxidant and detoxifying enzymes, bolstering the cells ability to resist oxidative stress, toxins, and other harmful stimuli, which can improve disease progression and prognosis [154, 155]

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