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GLP-1 agonists, by contrast, slow gastric emptying and directly suppress appetite through hypothalamic GLP-1 receptors

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The compounds safety and pharmacological profile have been comprehensively assessed in rodent models.In preclinical trials, including those involving ovariectomized (OVX) rat models, both low- and high-dose AOD-9604 regimens showed no significant toxicity

Endocrinology 163, bqac023

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