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Funding This work was supported by the National Natural Science Foundation of China (82372405, 81871752), the Key Research and Development Program of Hubei Province (2022BCA052), the Key Research and Development Program of Wuhan City (2024020702030105), the Fundamental Research Funds for the Central Universities (2042023kf0199), and the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University (ZNJC202014)

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