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Recent studies have identified following a regimen of moderate and prolonged treadmill training (30 m/min, 45 min/day, 5 days/week, 8 weeks) in rats of 48 h post MI, the SIRT1-p53 and SIRT3-FoxO3a-dependent signaling pathways are activated within the infarcted myocardium to reduce cardiomyocytes apoptosis and oxidative damage, showing exercise training to mitigate the early harmful effects of MI [53]

Hallmark pathological features of AD are the accumulation of A plaques and neurofibrillary tangles composed of hyperphosphorylated tau proteins (Islam et al., 2025)

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As expected, patients with active CD had a significantly lower red blood cell count and haemoglobin concentration in blood, higher platelets count and higher CRP level in serum compared with patients with inactive CD and controls

Additionally, lycopene has been observed to influence the permeability of the bloodbrain barrier, which may be compromised in certain neurological conditions [126]