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April 15, 2026 update: The FDA's revised 503A document removes TB-500 (both TB-500 acetate and TB-500 free base) from Category 2 and schedules it for PCAC review on July 23, 2026

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Treatment was also associated with reductions in body weight, high-sensitivity C-reactive protein level, systolic blood pressure and improvements in sleep-associated patient-reported outcomes

Adjusting to a balanced diet that emphasises low-glycemic index foods such as whole grains, lean proteins, healthy fats, and abundant vegetables can support insulin sensitivity and weight management [12]