Trametinib Size:5mg such as trans-cyclooctene (TCO) or

such as trans-cyclooctene (TCO) or norbornene derivatives

333 SMILES BrCCOCCOCCCC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

1038/s41586-020-2760-4

544 SMILES [N-]=[N+]=NCCOCCOCCOCCOCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

84 SMILES Cl

Trametinib Size:5mg such as trans-cyclooctene (TCO) orTrametinib (GSK1120212; JTP 74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib binds KRS MEK and disrupts RAF MEK. Product Name Trametinib Synonyms CAS Number 871700 17 3 Related CAS Molecular Formula C26H23FIN5O4 Molecular Weight 615. 404 SMILES CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC1=C(F)C=C(I)C=C1)C1=CC(NC(C)=O)=CC=C1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO, DMF