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10.1007/BF02263605

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When this regulation is disrupted, it can lead to pathological outcomes, including neurodegenerative diseases, cancers, and metabolic disorders (Ikeda et al., 2010

Primary Handling Editor: Nick Bernard, in collaboration with the Nature Immunology team

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1 Although toxic ingestions causing hepatic failure are usually in excess of 150 mg/kg, an increasing number of reports has arisen to suggest that lower doses of APAP may confer acute liver injury and liver failure