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10.1016/j.cmet.2014.10.006 36 KoethR

This can be especially beneficial for athletes and fitness enthusiasts who engage in intense training sessions

This prompted a randomized double-blind, crossover trial of amantadine, modafinil, and methylphenidate in MS

The mTORC1 inhibition by AMPK is accomplished by direct phosphorylation of the regulatory-associated protein of mTOR (Raptor) [264] and indirectly via activation of TSC2 [265, 266]

The most common imaging findings in the MMA patients in this study were subcortical white matter changes (37.8%), periventricular white matter changes (78.4%), ventricular dilation (29.7%) and cerebral atrophy (40.5%)

Its unique ability to cross the blood-brain barrier makes it particularly valuable for supporting cognitive function, mental clarity, and neuroprotection