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For 7 days, members of group 6 were given gentamicin and VCO (15 ml/kg p.o.)-iron oxide (Fe 3 O 4 ) NPs

It promotes the downregulation of pro-inflammatory plasma cytokines and an upregulation of anti-inflammatory plasma cytokines in animal models of metabolic syndrome

In the aortas of patients with AD, the levels of iron-death-associated molecules, such as transferrin receptor (TFR), Heme oxygenase-1 (HO-1), and ferritin, were increased, while the levels of iron-death-regulating proteins, including SLC7A11, GPX4, and FSP1, were decreased (Figure 1) ( FIGURE 1 This article aims to explore the potential connections and research significance of AD and ferroptosis by systematically reviewing the pathophysiological mechanisms of AD, as well as the characteristics of ferroptosis and its role in cardiovascular diseases

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Despite current treatments with antimalarial drugs, glucocorticoids, immunosuppressants, and monoclonal antibodies, a definitive cure remains elusive, highlighting an urgent need for novel therapeutic strategies