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The endothelial cells of the BBB tightly regulate cerebral entry of substances through junctional complexes, efflux transporters such as P-glycoprotein, and limited endocytosis

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This region has no known role in substrate binding or dimerization but could interact with protein partners through proteinprotein interactions

Liver transplantation Liver transplantation is the definitive cure for urea cycle abnormalities

NADP + supports the PPP to generate NADPH that is indispensable for reductive biosynthesis of nucleotides, amino acids, and lipids (56)

& Murakami, K