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That said, stronger is endpoint-dependent, dose ranges differ, and single-pathway selectivity is sometimes exactly what an experiment requires

JW: Resources, Supervision, Visualization, Writing review & editing

The rhythmic profile of circulating melatonin is lowered in patients with Parkinsons disease, especially in those who exhibit excessive daytime sleepiness (Videnovic et al

Bibcode:2010PNAS..107.9029K

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Emphasis has been drawn to studies which recruited larger sample sizes and have reported diagnostic biomarker sensitivities and specificities (whereas many studies have not investigated diagnostic sensitivity or specificity)