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Extracellular ATP, often released from damaged cells, binds to the P2X7 receptor, inducing potassium efflux and leading to NLRP3 activation [35]

Perez-Jimenez F, et al

Pharm Res (2019) 2(1):513

2 Materials and methods 2.1 Experimental mouse models In the acute SCI model, adult male C57BL/6N mice (1012 weeks, male, Nihon SLC, Shizuoka, Japan) were subjected to contusion injury at T9T10 using an Infinite Horizon Impactor (60 kdyn) or sham-operated by laminectomy only, as described previously (Figure 1A) (Scheff et al., 2003)