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In absence of MGMT-mediated demethylation in response to O 6 -Me guanine, MMR was shown to proceed in a futile cycle where thymidine mis-paired to methylguanine is continually excised and replaced

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For instance, the Infinium assay reported higher DNA methylation levels for CpGs that other assays identified as lowly methylated, while reporting slightly reduced DNA methylation levels for highly methylated CpGs