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We also assessed the localization of GLYR1 in Arabidopsis by generating two independent transgenic lines in the wild-type Col-0 background

Ca 2 enters mitochondria via the mitochondrial calcium uniporter in the IMM, activating dehydrogenases in the tricarboxylic acid cycle and enhancing OXPHOS and ATP production, ensuring energy supply matches demand in cardiomyocytes and regulating synaptic transmission and plasticity in neurons

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A point of interest however, is that the common mutations in the MMR genes that were identified in all four individuals tested, are likely to be LS predisposing gene mutations