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On the other hand, if the drug accidentally enters the left ventricular cavity, all body tissues may be exposed to the drug, reducing its therapeutic efficacy and leading to unexpected outcomes [185, 232, 233]

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Exposing neurons to pathological tau-seeding materials, typically derived by isolating insoluble tau fractions from human diseased brains, is one common method used to induce tau accumulation in mice 2,3,4,5,6,7,8,9,10,11 and primary neurons 4,5,10,12

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Combining KPV with a direct-acting anxiolytic peptide like Selank addresses both the inflammatory drivers and the neurotransmitter imbalances contributing to anxiety