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Furthermore, although iron promotes cell division and growth, it can also lead to cell damage, as excessive iron accumulation can be toxic, activating cell death signaling pathways through oxidative stress (20)

So, going back to kind of the old free radical theory of aging theory that basically the more free radicals that you have in your body or the more oxidants you have in your body the more that they are going to cause damage to different cell parts

Levine GN, Frei B, Koulouris SN, Gerhard MD, Keaney JF, Vita JA

Acknowledgements This project was supported by the National Natural Science Foundation of China (82272232, 82170775, 82370765, 82270802, 82100806, and 82300766) and the Open Project of Hubei Key Laboratory (2023KFZZ009)

Colbert also revived "The Wrd" under its original title

Maiese K, Chong ZZ, Hou J, Shang C (2009) The vitamin nicotinamide: translating nutrition into clinical care