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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

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Further transcriptional analysis revealed that irisin significantly downregulated the mRNA and protein expression levels of lactate metabolism-related proteins, including LDHA, PKM2, and HK2 (Fig

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Parletta, N., Milte, C

Aging activates nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase, xantine oxidase, cyclooxygenase and mitochondrial electron transport and inactivates the antioxidant system, including superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase, leading to an increase in ROS production and decrease in ROS degradation