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In the Arthritis Prevention In the Pre-clinical Phase of RA with Abatacept (APIPPRA) trial, at-risk individuals were defined as individuals with arthralgia, anti-CCP plus rheumatoid factor (RF) positive or high anti-CCP titers 3 x upper limit of normal plus RF negative, without synovitis at baseline (63)

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Res J Microbiol 13(1):2836 Hou Y, Yong Z, Wu W, Wu X, Xu J (2015) Antibacterial activities of rhubarb extract and the bioactive compounds against Salmonella

These evolutionary studies reveal that fewer clones of cancer cells from the primary tumor site can form metastases in distant organs compared to TDLNs, which might be attributed to the different selective pressures and microenvironments in these organs, such as the varying metabolites in distant organs (161, 162)

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