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Shen C, Reske SN

[PubMed: 8937515] 594

10.1038/nm.4001

Calling them interchangeable because they share a primary target is like saying a scalpel and surgical scissors are the same tool because they both cut

Patients exhibit a persistent, mild, systemic inflammatory state even in the absence of infection

The general principle: larger body mass means more adipose tissue to mobilize, more volume of distribution for the compound, and potentially higher receptor density