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Amitriptyline effectiveness in burning mouth syndrome: an in-depth case series analysis

The GPX4-GSH axis The antioxidant function of GSH is largely executed through GPXs and PRDXs, which catalyze reductive detoxification of lipid peroxidation 93

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This binding transcriptionally upregulates the expression of a series of key genes, including GCLC, GCLM (the light chain of GCLC), and xCT (system xc, responsible for cysteine uptake), thereby increasing GSH synthesis and cysteine uptake, thereby strengthening the cell's antioxidant defenses

The RanBP2/RanGAP1*SUMO1/Ubc9 complex is a multisubunit SUMO E3 ligase

A study indicates that 6% to 15% of opioid-nave post-op patients became chronic opioid users after major or minor surgery, including 4% of those who underwent total hip arthroplasty and 8% of total knee arthroplasty