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CD36 promotes iron accumulation and dysfunction in CD8 + T cells via the p38-CEBPB-TfR1 axis in earlystage hepatocellular carcinoma

Deficiency of lipin-1, a lipid metabolism-related molecule, downregulates FAO by inhibiting PGC-1/PPAR-mediated CPT1A/hepatic nuclear factor 4 alpha (HNF4) signaling and upregulates sterol-regulatory element binding protein (SREBP) to promote fat synthesis, thereby causing renal tubular epithelial cell damage and exacerbating fibrosis [52]

Furthermore, NAC (anti-oxidant via GSH upregulation) treatment increased GSH levels and clearly reduced lipid peroxidation, further supporting the notion that not only GPx4 levels but also GSH levels are a critical determinant for regulating lipid peroxidation and subsequent ferroptosis (Supplementary Fig

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FDA alerted consumers not to purchase or consume any of more than 25 different products marketed for weight loss because they contain undeclared, active pharmaceutical ingredients that may put consumers health at risk