Key manifestations of mitochondrial dysfunction Mitochondrial dysfunction is typically triggered by pathological stresses such as genetic mutations and ischemia, or by the aging process [7], leading to decreased efficiency of the electron transport chain, which in turn causes excessive ROS production and reduced ATP synthesis [8]
Brattstrm L, Lindgren A, Israelsson B, Malinow MR, Norrving B, Upson B, and Hamfelt A (1992)
Overcoming oxidative stress in a redox environment is applicable to treatment outcome
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Conversely, promoting mitochondrial fission, via dynamin-related protein 1 (DRP1), inhibits MAVS activity during viral infection 214,215
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