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5,299 This microvascular impairment reduces oxygen and nutrient delivery to peripheral nerves, leading to nerve ischemia and hypoxia

During the degranulation and release, perforin polymerizes and forms pores in the target cell membrane to facilitate granzymes delivery into target cells, inducing apoptosis through different pathways, including caspases-3/7 activation, cytochrome C release from mitochondria driven by Bak/Bax, and IL-1 regulation by caspase-1 [32]

Additionally, the pQCT findings imply that the enhanced cortical BMC might stem from an expanded cross-sectional bone area, suggesting that the femur and L6 vertebrae could have seen heightened bone mineralization