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Biochemical and Biophysical Methods in Molecular and Cellular Biology

Mitochondrial DNA (mtDNA) depletion and mutations in certain mitochondrial genes are linked to reduced insulin secretion and increased oxidative stress, although studies on the exact mechanisms are scarce ( 2.4.1 Basic science research Similarly, in the context of PD, mitochondrial dysfunction can drive neurodegeneration

42,43 Cholesterol-enriched lipid droplet formation in podocytes, combined with dysregulated insulin signaling and hyperglycemia, exacerbates podocyte death and detachment

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10.1126/science.122.3168.501 41 EagleH.PiezK

[DOI] [PubMed] [Google Scholar] 2.Yang Y., Shi Y