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FIGURE 1 2 Review methodology In accordance with the Preferred Reporting Items for Systematic Reviews and Meta - Analyses (PRISMA) guidelines, we conducted a systematic review to explore the regulatory role of ferroptosis in MM

96 Coenzyme Q10 Coenzyme Q10 (CoQ10) is needed for normal mitochondrial function in cells throughout the body and is especially concentrated in heart muscle cells

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McKennaMJMedvedIGoodmanCABrownMJBjorkstenARMurphyKTet alN-acetylcysteine attenuates the decline in muscle Na + , K + -pump activity and delays fatigue during prolonged exercise in humans

Differentially expressed genes were then identified using DEseq2 (an R package for differential expression analysis) 44

This protection is largely achieved through the reduction of oxidized glutathione (GSSG) to reduced glutathione (GSH), the major intracellular antioxidant in erythrocytes and most other cells