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The eumelanin-to-pheomelanin switch A second, more subtle mechanism involves the type of melanin produced rather than the total amount

10.18203/2319-2003.ijbcp20194773 553

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Subsequent intravenous (IV) administration to both mammalian liver cell-lines (HepG2) in vitro and CTLN2 mouse model in vivo corrected the subcellular localisation and expression of a fully functional citrin protein in liver mitochondria, i.e., almost equivalent to 25% of wild-type expression levels [134]

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Immunity 9 , 405411 (1998)