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PPIs work by blocking gastric H + K + -ATPase (EC 3.6.3.10), which is responsible for pumping H + ions from within gastric parietal cells into the gastric lumen, where they react with Cl ions to form hydrochloric acid (22) (Figure 1)

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The overdose of vitamin B12 is very rare because its a water-soluble vitamin, which means excess amounts are usually flushed out through urine

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PMID: 30241623.