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Met is first metabolized by methionine adenosyltransferase (MAT) to form S-adenosylmethionine (SAMe, which is also abbreviated as AdoMet) (Figure 1)

238 The second generation of HAPs consists of compounds that have been structurally modified at the C2 and C6 positions on the basis of the first generation

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Wnt5a activats Wnt/PCP pathway, upregulating Ras-related C3 botulinum toxin substrate 1(Rac), which can activate JNK, thus aggravating IR in adipose tissue

doi: 10.1186/s13578-022-00764-z 84 LiuTJiangLTavanaOGuW

Histone methylation usually compacts the DNA, restricting the access of transcription factors necessary for gene expression