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Additionally, therapeutic interventions that target MAPK signaling, such as the use of sakuranetin, have demonstrated efficacy in reducing eosinophilic lung inflammation and Th2/Th17 cytokine production by inhibiting the activation of ERK1/2, JNK, and p38 MAPKs [165]

Growing evidence indicated that microbiota dysbiosis, occurring when the diversity, composition, and/or functions of the intestinal microbiome are disrupted, could contribute to the alteration of the IEB with implications in the development, progression, and symptom flare-up of several diseases

Through weakening innate and adaptive immune responses, zinc deficiency diminishes the capacity of the body to combat pathogens (63, 64)

What Foods Contain Vitamin B12 for Dogs

**Pernicious Anemia:** Management of pernicious anemia, a condition characterized by the inability to absorb vitamin B12 from the gastrointestinal tract

6.2 DR Almost all patients with diabetes develop DR