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Toxicology 149:4350 Thomas C, Mackey MM, Diaz AA, Cox DP (2009) Hydroxyl radical is produced via the Fenton reaction in submitochondrial particles under oxidative stress: implications for diseases associated with iron accumulation

Liu G, Sun X, Bian J, Wu R, Guan X, Ouyang B

Kanski J, Aksenova M, Stoyanova A, Butterfield DA

Studies show that the transcription factor FOXO4 plays a protective role in senescent cells by maintaining the protein p53 in a sequestrated state within nuclear structures, thereby inhibiting its ability to initiate apoptosis