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Weight can be seen as one of the factors in varicose veins because it increases intra-abdominal pressure

After mating, the adult female worm can produce thousands of microfilariae that migrate into the bloodstream

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Funding This work was supported by grants obtained by IDI-IRCCS from the Italian Ministry of Health (Ricerca Corrente 2023 and 2024 and RF-2019-12368888 grant), LazioInnova (Grant A0375-2020-36568 UTV-IDI), European Union-NextGenerationEU through the Italian Ministry of University and research under PNRR-M4C2-I1.3 Project PE_00000019 HEAL ITALIA, and the European UnionNext Generation EUPNRR-MAD-202212375740 M6C2Investimento 2.1 Valorizzazione e potenziamento della ricerca biomedica del SSN, funded by the Italian Ministry of Health

2.2 Pathophysiological mechanisms of the systemic inflammatory response 2.2.1 Tumor-Induced systemic inflammatory microenvironment The association between chronic inflammation and the development and progression of cancer is a fundamental tenet of oncology (3941)

More precisely, this study is the first to reveal that induction of autophagy exerts a protective role against the intrinsic metabolic stress and attempts to antagonize degenerative processes in normal appearing vitiligo skin, where melanocytes and fibroblasts are already prone to premature senescence