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ROS has also been shown to increase the expression of TGF-1 signalling, with downstream effects including elevated expression of collagen, fibronectin, bFGF, and matrix production 104,137

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Melatonin was most effective in enhancing learning ability in senescence-related and metabolic AD models and in correcting memory deficits in toxin-induced AD models

This is mediated via TGF-1 upregulation and results in peritoneal EMT (Yang et al., 2017)

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Interaction with the Somatotropic Signaling Network The somatotropic axis represents a complex regulatory network involving hypothalamic signals, pituitary responses, and downstream molecular mediators such as insulin-like growth factors