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3) Can this defect be reversed

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Meanwhile, the conformational changes of F279 6.51 and W276 6.48 also cause rotameric switches of F312 7.42 and Y313 7.43 and the repacking of the inter-helical hydrophobic contacts between TM6 and TM7, which leads to the inward shift of the cytoplasmic end of TM7 (Fig

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Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor , and the coactivator peroxisome proliferator-activated receptor coactivator-1