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Once in the nucleus, -catenin displaces the corepressor Groucho and binds to the DNA-bound transcription factors T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) to activate Wnt-dependent gene expression (Figure 1)

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*Correspondence: Jian Yang, [email protected]

Dermatologists recommend wearing sun protective clothing as a first line of defence and high protection factor, broad-spectrum sunscreen as a second line of defence