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Table 1 Human studies of TMAO as a potential novel and independent risk factor for predicting clinical risk of atherosclerosis (AS) and prognostic stratification

Dec 25 2019;12(1)doi:10.3390/nu12010058 Chien YJ, Chang CY, Wu MY, Chen CH, Horng YS, Wu HC

Lastly, while APOE effects dominated brain profiles, sex effects were more prominent in the periphery, which was also in accordance with a previous study in older (16 months old) APOE-TR mice (Shang et al., 2020), suggesting that regardless of age APOE has a major effect on brain bioenergetics

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71 Furthermore, studies have shown that the levels of PUFAs in young and middle-aged individuals are significantly correlated with neutrophil function