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Mechanistic evidence relies heavily on animal studies (e.g., mouse neurotransmitter experiments) with insufficient large-scale human randomized controlled trials (RCTs) to confirm causality

Muranyi M, Ding C, He Q, Lin Y, Li PA

Adenosylcobalamin Injections: Adenosylcobalamin is less commonly available as an injection but may require similar storage conditions to other B12 formulations

54 However, previous studies have also demonstrated that MSCs are capable of secreting anti-inflammatory cytokines, anticatabolic mediators, and growth factors when cultured under IDD-like conditions both in vitro 55 and ex vivo, 56 hence demonstrating an immunomodulatory effect on resident IVD cells

For instance, Huang et al

& Kato, N