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10.3889/oamjms.2017.122 83 GicquiauxH.LecatS.GaireM.DieterlenA.MlyY.TakedaK.et al

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Meanwhile, human clinical data are generally characterized by small sample sizes and short follow-up periods, with inadequate adjustment for confounding factors such as diet and concurrent medications, making it difficult to confirm the long-term efficacy and safety of Clostridium interventions

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