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However, curcumin induces the modification of cysteine residue 151 in Keap1, leading to conformational changes that hinder Keap1s ability to mediate Nrf2 ubiquitination by the Cul3 complex

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The process is usually quick, lasting only a few minutes

In human anecdotal reports, the most commonly cited side effects include: Mild nausea (especially with oral dosing on an empty stomach) Lightheadedness or dizziness Headache Slight fatigue in the first few days Injection site irritation (minor pip, if injectable) Honestly, most people report zero sides

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Do your skin concerns include sensitivity or wrinkles