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While no widespread anaphylactic reactions were reported in clinical trials, there has been an isolated case of a severe local hypersensitivity reaction characterized by intense redness, swelling, and urticaria (hives) at injection sites in a patient who developed anti-sermorelin antibodies

Circulation 142 , 22992311 (2020)

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Common side effects include urinary tract infections, genital fungal infections, and dehydration due to the diuretic effect

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This "clean" pharmacological profile makes Ipamorelin the preferred reagent for researchers aiming to isolate the somatotropic (growth hormone) pathway without introducing the confounding variables of stress hormone elevation or appetite stimulation