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In SPMS, characterized by steady deterioration without acute attacks, treatment strategies often involve continuing or altering DMT used during the earlier RRMS phase, such as interferon beta, or considering immune-modulating agents, such as methotrexate, cyclophosphamide, or glucocorticoid pulses [142, 143]

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8 weeks (11 vials): 33 mL 4 10 mL bottles 12 weeks (17 vials): 51 mL 6 10 mL bottles 16 weeks (22 vials): 66 mL 7 10 mL bottles Alcohol Swabs: One for the vial stopper + one for the injection site each day

Competitive endogenous RNAs (ceRNAs) act as sponges for miRNAs, ceRNAs can bind to miRNAs and reduce the abundance of miRNAs in the cell, thus reducing the inhibitory effect of miRNAs on target genes

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