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BAs function as signaling molecules through various receptors, including farnesoid X receptor (FXR), vitamin D receptor, pregnane X receptor and members of the G-protein-coupled receptor superfamily, to regulate their own synthesis as well as other metabolic processes, such as glucose, lipid and energy metabolism (Arab et al., 2017)

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The results presented herein provide further evidence that the effects on the renin cascade extend to reduced ALD levels beyond that achieved with RAAS blockade alone

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