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A.KhanS.SikderO.et al (2020)

Furthermore, GDF15 has been implicated in disorders associated with central sensitization, highlighting its relevance to FM pathophysiology 11

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This decreased sensitivity is due to the cold tumor effect that CAFs confer, caused by the recruitment of Tregs via TGF, MDSCs via complement signaling, and CXCL16 and CTL exclusion ( The key role played by CAFs in TNBC opens the door to new therapeutic strategies that target CAFs, such as fibroblast grow factor receptor (FGFR) blockade with erdafitinib